Growing up in Hollywood, Eliza sometimes sang on her father's demos and soundtracks, along with her brother Tony Gilkyson, who later became a member of the rock bands Lone Justice and X and performed on her records. Though uncredited, she can be heard singing with her father in the Disney TV movies The Secret of Romney Marsh (1964) and The Legend of Young Dick Turpin (1965). (She also had a sister, Nancy Gilkyson, who became an executive at Warner Bros. Records and sang on her records.) In her late teens, she moved to Santa Fe, New Mexico, where she raised a family and released her first album, Eliza '69, on Mont Clare Records. (Her son Cisco Gilliland [aka Cisco Ryder and Cisco Gilkyson] later became the percussionist in her backup band, and she also had a daughter, Cordelia Castillo [aka Delia Gilkyson], who later sang on her records.) Her second foray into recording was her 1979 LP Love from the Heart, released under the name Lisa Gilkyson by Helios Records. Over the next several years, she moved to Austin, Texas, then back to Los Angeles, then to Taos, New Mexico. Again as Eliza Gilkyson, she signed to Gold Castle Records and released Pilgrims in 1987. The label marketed the album as a new age recording, a tag Gilkyson later rejected. She followed Pilgrims with Legends of Rainmaker (1989), which featured her cover of "Greenfields," and a duet with Bonnie Raitt on her own composition "Rosie Strike Back," a rock & roll song decrying spousal abuse, which had already been recorded by Rosanne Cash on her 1987 album King's Record Shop. Unfortunately, Gold Castle went bankrupt, and Gilkyson was without a record label for several years. In 1993, she was signed to Private Music, which issued Through the Looking Glass that summer. She next co-wrote eight of 14 songs and sang and played on harpist Andreas Vollenweider's album Eolian Minstrel, released in November, then toured with him. She moved to Europe and got divorced from her husband of 14 years, leaving her American career behind. In 1994, she released an album called Undressed overseas on Revelizations Records. She returned to the U.S., settling again in Austin, and reintroduced herself to her homeland with Redemption Road, released in September 1997 on Silver Ware. "Prayer 2000," a song from the album that she co-wrote with Mark Andes (formerly of Spirit, Jo Jo Gunne, Firefall, and Heart), was later covered by Priscilla Herdman. In 1999, Gilkyson formed her own Realiza label and issued Misfits, a collection of previously unreleased archival recordings. She then signed to the independent folk label Red House Records for a new album, Hard Times in Babylon, released in October 2000. The opening song, "The Beauty Way," co-written with Andes, was later covered by Ray Wylie Hubbard. Lost and Found followed in April 2002. Three months later, she teamed up with Ian Matthews and Ad Vanderveen for the trio album More Than a Song, released by Perfect Pitch. Her next Red House solo album was the politically oriented Land of Milk and Honey (March 2004), featuring the previously unrecorded Woody Guthrie song "Peace Call," with backup vocals by Mary Chapin Carpenter, Patty Griffin, and Iris DeMent, which earned a Grammy nomination for Best Contemporary Folk Album. In July 2005, she self-released RetroSpecto, a collection of rare and out of print material. Paradise Hotel, her fourth Red House release, appeared the following month. Your Town Tonight, Gilkyson's first live disc, was released two years later, followed by Beautiful World in May, 2008. In 2011, Gilkyson joined labelmates John Gorka and Lucy Kaplansky under the banner Red Horse and released an eponymous album.