Based in Brooklyn, NY, Deupree's most widely known project is as one third of Prototype 909, a group that also included Dietrich Schoenemann and Jason "BPMF" Szostek. The group was most famous for their live performances and gear, such as rare keyboards, drum machines, and refusal to use a DAT player, holding prerecorded music. The band released four full-length albums, Acid Technology (Instinct, 1993), Live 1993-1995 (Instinct, 1995), Transistor Rhythm (Instinct, 1995), and Joined at the Head (Caipirinha, 1997). Prototype 909 dissolved in the late '90s, but continues to work on projects together and independently.

Deupree is also half of SETI, a duo named after the research experiment to pick up radio signals from aliens. A relative suggested the name to Deupree for his production alliance with Savvas Ysatis (Omnicron), a longtime friend. Both Ysatis and Deupree wanted their music to reflect the mood of the project, which resulted in minimalistic and often experimental sounds and samples. SETI put out three full-length releases, SETI (Instinct, 1993), Pharos (Instinct, 1994), and Ciphers (Instinct, 1996). Despite Deupree's worries concerning the use of the name of the highly sensitive experiment, scientists at the SETI Institute actually praised the duo for their work. For Pharos, the Institute gave the group sound samples from space and spoken interviews to use on the album. In 1996, Savvas and Deupree formed the label Index, which only released one 12" EP with four tracks from various artists, including Prototype 909's Dietrich Shoenemann. The record is now distributed by 12K Records.

In 1993, Deupree started his solo project, Human Mesh Dance. Unlike Prototype 909's knob-tweaking, classic techno sound, Human Mesh Dance allowed Deupree to show his softer, ambient side at the same time that Prototype 909's popularity was rising. His first full-length as Human Mesh Dance was Hyaline (Instinct, 1993). In 1994, he followed with the full-length Mind Flower, again on Instinct. Theseceretnumbertwelve was released in 1997 under much acclaim on 12K Records and marked a new point in Deupree's independence as a solo artist. 12K is based in New York and has released a slew of CDs, most in limited editions of 500 or 1,000.

In 1997, Deupree teamed up with Ysatis again and released the CD Arc vs. Tiny Objects in Space under the corresponding names. In 1998, 12K released the CD Alphabet Flasher by Drum Komputer, a name Deupree and former Prototype 909 colleague Schoenemann use when they produce together. That same year, Deupree's solo project Comma came out in a limited 500 release, a year later a limited release with Richard Chartier called Spec returned him to a paired-off effort. In April 2000, the album .N was released, and in July, Deupree teamed with Tetsu Inoue for Active/Freeze. A month later, the full-length album Polr was released on Frank Bretschneider's German label Raster Music.

Besides music, Deupree has had an artistic role in the electronic music culture. Instinct Records gave him an outlet for his work to be noticed when he took over as head graphic design artist. Since his departure from Instinct, he has been highly involved with Caipirinha Productions, the producers of the much-acclaimed electronic music documentary Modulations. Deupree worked on the visually based, futuristic film Synthetic Pleasures, where he took charge of the graphic design work and contributed to both of the film's soundtracks. Making a bold shift in the direction of his sound, Deupree began to focus more on textural elements with Stil. in 2002. He also began a period of heavy collaboration, working with artists divers in scope such as pianist Kenneth Kirschner, microsound guru Frank Bretschneider, atmospheric minimalist Richard Chartier, and guitarist Christopher Willits.

In 2004, Deupree launched the Happy imprint, the byproduct of a dissatisfaction with the lack of proper exposure to Japanese pop outside of Japan. 2005 found Deupree remixing such experimental music luminaries as Philip Glass and Ryuichi Sakamoto, as well as an album-length project of sound reconstruction for Japanese trio Eisi, entitled Every Still Day. After several years of team-ups, in 2006, he returned to the console as a solo artist and released the beautifully textured Northern, followed by a limited edition of experimental field recording samples, titled 1AM.